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ex-Member
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Join Date: Sep 2006
Posts: 110
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ex-Member
Join Date: Sep 2006
Posts: 110
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Creatine is a nutritional supplement, a bit like a vitamin. Creatine does not, even in theory increase the formation of dopamine. Dopamine reduces muscle contraction. Creatine instead increases energy production in muscles.
The clinical trial is based on a prior study of Creatine in the treatment of Parkinson's Disease :
Neurology [2006] 67 (7) : 1262-1264 (Bender A, Koch W, Elstner M, Schombacher Y, Bender J, Moeschl M, Gekeler F, Muller-Myhsok B, Gasser T, Tatsch K, Klopstock T.) Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial.
Creatine was shown in this study to have no effect at all in reducing Parkinson's Disease. In the words of the study it "had no effect on overall Unified Parkinson's Disease Rating Scale scores". The Unified Parkinson's Disease Rating Scale is the main method of assessing whether a product improves Parkinson's Disease.
So the use of Creatine in Parkinson's Disease is not only fundamentally flawed in theory, because it has no involvement in Parkinson's Disease, but has already been shown in practice to be of no benefit. So it is difficult to see why the large clinical trial of Creatine in Parkinson's Disease is even taking place.
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