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Magnate
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Join Date: May 2007
Posts: 2,049
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Magnate
Join Date: May 2007
Posts: 2,049
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I did 23andme which is an autosomal testing service online. I had almost my entire genome typed. They skip a small portion of genes. They also do your mitochondrial genes too.
I was gene typed, in other words, they analyzed my genes and pointed out alleles in snps that are mutated in people that have the disease. Same with MS. The genes only point to propensity, and are not diagnostic, however, if you carry enough mutations, you can start to draw some conclusions.
They typed my Cytochrome p450. Three of my enzyme systems have issues. CYP2C9*1 is not functioning, and CYP2C9*2 is poorly functioning. CYP1A2 is metabolizing slowly as well. There are additional genes causing metabolism issues. I also have a problem with statins, in my genotype, statin myopathy risk is 5x higher. I found out that I have an issue with serotonin levels being too high.
When you get all the raw data, you can do an add-on to the 23andme, via Snpedia. This automatically references all your snps, so you can click on the snp and get citations! It refers you to several data bases and google scholar citations.
You can also take your raw data and run it thru Promethease, which is yet another service, (free) that accepts 23andme raw data. (They charge $2 via Amazon to expedite your download-it's very long otherwise) There are several free programs that take the data for anthropology use or medical use.
23andme is very user friendly. It's easy, colorful and interactive. You can go as deep as you want into the data. They warn you and allow you to NOT view certain data, such as Alzheimer's risk, if you choose not to. You can lock it out of view.
I recommend it, for the drug metabolism testing alone.
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