Thanks!
This is the abstract on PubMed:
Quote:
Diabetes Care. 2012 Mar;35(3):584-91.
Impaired Glycemia and Diabetic Polyneuropathy: The OC IG Survey.
Dyck PJ, Clark VM, Overland CJ, Davies JL, Pach JM, Dyck PJ, Klein CJ, Rizza RA, Melton LJ 3rd, Carter RE, Klein R, Litchy WJ.
Source
Corresponding author: Peter J. Dyck, dyck.peter@mayo.edu.
Abstract
OBJECTIVE To test whether diabetic polyneuropathies (DPNs), retinopathy, or nephropathy is more prevalent in subjects with impaired glycemia (IG) (abnormality of impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or impaired HbA(1c) [IA1C]) than in healthy subjects (non-IG). RESEARCH DESIGN AND METHODS Matched IG and non-IG volunteers were randomly identified from population-based diagnostic and laboratory registries, restudied, and reclassified as non-IG (n = 150), IG (n = 174), or new diabetes (n = 218). RESULTS Frequency (%) of DPN in non-IG, IG, and new diabetes was 3 (2.0%), 3 (1.7%), and 17 (7.8%) narrowly defined (no other cause for polyneuropathy) and 19 (12.7%), 22 (12.6%), and 38 (17.4%) broadly defined. Mean and frequency distribution of composite scores of nerve conduction and quantitative sensation tests were not significantly different between IG and non-IG but were worse in new diabetes. Frequency of retinopathy and nephropathy was significantly increased only in new diabetes. In secondary analysis, small but significant increases in retinopathy and nephropathy were found in IGT, IFG, and IGT combined groups. CONCLUSIONS In population studies of Olmsted County, Minnesota, inhabitants, prevalence of typical DPN, retinopathy, and nephropathy was significantly increased only in subjects with new diabetes-not in subjects with IG as defined by American Diabetes Association (ADA) criteria of abnormality of IFG, IGT, or IA1C. For atypical DPN, such an increase was not observed even in subjects with new diabetes. In medical practice, explanations other than IG should be sought for patients with atypical DPN (chronic idiopathic axonal polyneuropathy) who have IG.
PMID:
22355020
[PubMed - in process]
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from
http://www.ncbi.nlm.nih.gov/pubmed/22355020
This quote from the Mayo article is revealing:
Quote:
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Due to the risk of complications from overtreatment, doctors should not treat prediabetes if their intention is to prevent the development of diabetic polyneuropathy, the researchers said.
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Given that impaired glucose utilization that appears in patients,
involves LOWS predominately, and not HIGHs for long periods, it
is very appropriate to not-treat with insulin or oral drugs.
In fact all the drugs other than insulin are quite awful with serious
side effects long term. Applying appropriate dietary measures for patients is not discussed in that study.
Medicine and supplement research typically goes back and forth
with studies for quite a while before we get a sense of what direction to
take. In fact drug companies WITHHOLD their negative studies typically so doctors and patients cannot see how weak some of the "positive" ones really ARE.
I think it is prudent that patients on the path to diabetes control their diet as much as possible. Also patient selection was not described much at all. Choice of participants is very critical in studies as they
may have other factors working for them. That community may have very "clean" lifestyles being a farming state, etc. In a study like this
were run in another location, where lifestyle would be different, it might show different results. We don't even know as yet what is causing the "diabetes/metabolic syndrome" epidemic yet. Diet, is implicated but not proven yet. It is just something we as patients can
control.
I think the debate will be ongoing on this subject:
Here are some examples of other papers on this subject:
http://www.ncbi.nlm.nih.gov/pubmed/18195653
http://peripheralneuropathycenter.uc...diabetes.shtml
http://care.diabetesjournals.org/con.../1/207.extract
http://archneur.ama-assn.org/cgi/con...ract/63/8/1055
This study on Medscape, came to different conclusions and had
a larger study group as well:
http://www.medscape.com/viewarticle/465767_3
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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