Originally Posted by fmichael

Hi. Sorry to be late on this, but I've been given something that's nothing short of awesome for flairs.

In addition to the backdrop of Oxycontin/oxycodone, Xanax and Baclofen, I've been - as disused nere months ago - Neudexta, a combination of 20 mg of dextromethorphan HBr (DM) and 10 mg of quinidine sulfate. DM - widely used as an over the counter cough suppressant - just happens to be a powerful NDMA-receptor antagonist, second only the ketamine. Its downside in pain relief is that it's quickly metabolized by the liver. But, it turns out that quinidine - widely used in substantially larger doses years ago as a tricyclicate antidepressant before it was found to cause cardiac arrhythmia in too many people - completely blocks the metabolism of DM, for 4 - 6 hours at a time. To which my doctor adds a prescription for compounded DM in capsules, 30 mg each. (While Neudexta is covered by my insurance, DM is not, but its pretty cheep: 60 capsules cost me $56.)

So, with the worst of flairs, as I was having a few minutes ago, I just take the foregoing - including 90 mg of DM - and I'm right as rain, and heading out to see a movie in few minutes!

One note of caution: even with only 10 mg of Quinidine, Neudexta is contraindicated to anyone throwing a "long Q - T interval" on their EEG. So "pre-clearance" from your internist is a good idea.

I hope this is useful.

Mike