Here are some really surprising finds from current research that leave me wondering again why so much effort is spent only on dopamine?

Serotonin can turn ldopa into dopamine . Some scientists think that this is basis for dyskinesia though still being hotly debated.

Serotonin actually mediates the pathologic misfolding of alpha-Synuclein! Gak.
It is now widely believed that amyloid fibrils (gunk that results from loss of dopamine aka Lewy Bodies) that are last stage of rogue protein behavior are benign. The toxic stage is intermediate level and this is where Serotonin somehow stops the misfolding and stabilizes the a-Synuclein.

Is this how we are losing other neurotransmitters? Are they jumping in to help or trying to compensate for dopa sensitivity? Anyway, as always more questions and no answers. Seems like a lot more research in this area might reveal how other neurotransmitters besides dopamine are not lost in large proportions too?

Further, even though we reportedly lose Serotonin first; why is it I had slightly elevated levels of its metabolite upon testing two years ago. In fact, research reveals that Serotonin is actually increased in the S. Nigra- maybe it is a compensatory measure?

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation



Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease.


Okay then, will they please explain why many people report Parkinsonism as an SSRI side effect or why in others it is harbinger to full-blown PD? Hardly seems like all this is mere coincidence?

Looks like there may be some benefit in learning more about the relationship between serotonin and dopamine. At any rate, dopamine and a-Synuclein form merely the tip pf the iceberg.