It will challenge your system by requiring a lot of effort to replace the plasma. If it was up to me, I would not do it.

Here is a comment I found: Common reactions to donating plasma seem to be short-term and include dizziness, fainting and vomiting stemming mostly from not drinking enough water. Plasma is mostly water and in a typical donation session you lose about a half a gallon. Fatigue is also a commonly reported side effect.

If you do it, you body recovers within 48 hours so you could use your experience of recovery to determine how it effects your system.

It also will cause you to have a physical including blood work before every draw. I question whether you should drive yourself home after. At least not the first time.

My best to you.