My GP put me on Zoloft (50–75 mg) for depression on April 2010. It did help remarkably; however, after a year of taking it I started to feel some problems in walking, worse slowness and tremors in my low chin – syndromes very similar as mrsD described. My instinct tells me this may have something to do with Zoloft and started to taper off on June 2011. But this did not help the symptoms and the withdrawal was also tremendous. I was diagnosed PD on August 2011 by one neurologist and two movement disorder specialists. I am now on Azilect (1 mg) and small dose of Mirapex.

As SSRI use appears to be associated with the development of movement disorders, either a direct result of the drug or exacerbation of an underlying condition, my depression issues remain unaddressed. Plus I am on Azilect (MAO-b). When I saw my specialist last time, he mentioned to me to start Zoloft again at 5 mg along with Azilect. What is the right way to address the depression? I feel this may help other symptoms if do it correctly… Thanks!