--but it could be a symptom of a lot of other things as well.

Interesting that your first skin biopsy picked up some "mild changes" in the fibers; can you elucidate? (What did the report actually say?) Often, symptoms are not correlated with degree of damage; there've been many people with "mild" damage of small fibers who have considerable pain or numbness.

Sometimes, also, the damage is patchy and may not be completely picked up at a specific skin site.

One of the good things about the relatively non-invasive nature of skin biopsy is that it can be done over and over again and comparisons made from sample to sample.