IVIG for 3 years now, it's the balance of pre-meds and infusion rates that are the KEYS. Not enuf or too much of one or the other can give you either/or the headache from DEEP SOUTH [sorry those in the South, I mean the other kind of south..] or the 'runs'. Nurses should know what to do..that's why I'd posted that Immune Deficiency Nurses guide in a prior related post...IF they don't KNOW and do That stuff.. well, snuff isn't UP to par! It's the good nurses who plain old know the differences about IVIG in particular who are, in my book, VERY SPECIAL! I for one, appreciate the 'art' of the nurse and the processes. - j