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Old 03-10-2012, 03:10 AM
imark3000 imark3000 is offline
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Join Date: Nov 2007
Location: Calgary-Canada
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imark3000 imark3000 is offline
Member
 
Join Date: Nov 2007
Location: Calgary-Canada
Posts: 821
15 yr Member
Default A question to RLSmi !

Quote:
Originally Posted by RLSmi View Post
The sequence of physiological reactions leading to dopamine is;

l-phenylalanine -> l-tyrosine -> l-DOPA -> dopamine.

Humans can't make l-phenylalanine, it has to be provided in the diet, however we can make l-tyrosine, although it is present in dietary protein.

If you eat food with adequate protein in it you get plenty of l-phenylalanine and l-tyrosine in your diet from the breakdown of the protein into its amino acids.

Healthy dopaminergic neurons can perform all three of these reactions provided there are adequate enzymes and co-factors. As I understand it, in PD the problem is the loss of healthy neurons, not a lack of either l-phenylalanine or l-tyrosine for dopamine production.
But I understand that L-dopa treatment implies that L-dopa is converted to dopamine by same sick neurons? If so why these cells fail to do the
l-phenylalanine -> l-tyrosine -> l-DOPA conversion?
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Imad
Born in 1943. Diagnosed with PD in 2006.
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