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Member
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Join Date: Oct 2006
Location: dx'd4/01@63 Louisiana
Posts: 562
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Member
Join Date: Oct 2006
Location: dx'd4/01@63 Louisiana
Posts: 562
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Imad,
As I understand, the remaining few healthy dopaminergic neurons can't keep up with the need for dopamine because the first and second reactions which produce tyrosine and DOPA are rate-limiting, or slower. However, as long as there are some neurons still functioning, they can convert exogenous l-DOPA to dopamine by that faster final reaction.
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