Quote:
Originally Posted by RLSmi
Imad,
As I understand, the remaining few healthy dopaminergic neurons can't keep up with the need for dopamine because the first and second reactions which produce tyrosine and DOPA are rate-limiting, or slower. However, as long as there are some neurons still functioning, they can convert exogenous l-DOPA to dopamine by that faster final reaction.
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OK, so why does it take so much longer for our ldopa (sinemet) to take effect than it does the 5-hour drink? And I mean, it' s a huge difference! With that analysis, it should actually take longer for the drink to have an effect, since those sick dopamine neurons are having to go through three conversions (LP-tyrosine-ldopa-dopamine) instead of just one (ldopa-dopamine).
We are wondering if we might shouldn't instead be looking at the drink's impact on epinephrine as the causative factor for us...