Hi Imad, several years ago my husband did take an NADH preparation. I no longer remember why we stopped it. The reasoning for starting it was that it is an important part of complex 1 of the electron transport chain, and thus mitochondrial function. I think my husband's use was prompted by information that dysfunction of complex 1 was operant in PD. He could never discern a difference if he took the supplement or not. A very dated article about adult mitochondrial cytopathy has a listing of vitamins and supplements recommended; Dr. Cohen recommends niacinamide which is a precursor to NADH. Literature written by Cohen guided us during the first years we were attempting to impact PD
http://www.emdn-mitonet.co.uk/PDF/CO...MitoAdults.pdf
there has been more recent info on NADH, thou I do not keep up with it any longer. Madelyn