Hello all,

I just joined today for the purpose of asking a question. I searched through the forum and was unable to spot a similar topic, though of course it's possible I missed it. I apologize if I'm being redundant.

My question: are choline supplements contraindicated with Mestinon?

I don't thoroughly know the science behind behind this. I know that Mestinon prevents the breakdown of acetylcholine so that more can be absorbed.

This is similar, in a way, to an SSRI; an SSRI inhibits the reuptake of serotonin so that more can be absorbed. And I know that if one is on an SSRI, serotonin supplements are contraindicated as they can cause serotonin syndrome. This led me to wonder about choline supplements in combination with Mestinon; are they contraindicated? Would taking them together run the risk of cholinergic shock?

I currently take Mestinon, 60mg four times daily. I don't take it for myasthenia gravis, however; I take it for dysautonomia and gastroparesis. I'm curious and would like to try a choline supplement, but am wary of possible contraindications in light of what I know about SSRIs.