Side effects from R-lipoic may be irritability or anxiety. Not all of our posters here get this. But I did and a few others.

Take the R-lipoic on an empty stomach for best absorption.

You may not see anything at all.

Acetyl Carnitine comes in 250mg also...from Puritan's pride.
The carnitine allows your body to metabolize fatty acids instead of glucose when glucose is low. So it might really give you a boost.

But Carnitine really only has GI symptoms in excess of 10 grams a day! We don't use anything near that dose at all!
It is really easy to tolerate. It just costs alot of money, like the CoQ-10 does.

I just bought Qunol (ubiquinol) at Costco this week, on a big sale. I've just finished 300mg CoQ-10 I found in my packing box for upNorth! I bought this last summer at SAMs club. I am just starting to see some effects (less need for naps for example) after 60 caps! one a day.

I'll do the Qunol and see if there is any change. I think CoQ-10 is a slow slow response depending on the quality of the product you choose.

Supplements that affect metabolism, work very slowly... you have to be observant to really feel them sometimes.