I started with 2x50mg/day. After 2 mos noticed decline in efficacy. Took a break for a week and found underlying nerve sensitivity MUCH greater. Painkiller can allow u to aggravate underlying condition and not know it AND may actually cause greater nerve sensitization. Now I am using 25mg only occasionally, and mix in other modalities--TENS, PainGone Pen, white willow(mild form of aspirin), etc.