I've been doing every other day, or less, for several years now. It had just gotten too expensive and also I was running out of body area that wasn't covered in huge whelps from the shots. I did have one exacerbation when I went too long without the C where I ended up back in the wheelchair, but other than that I've been about the same. It's against my dr's advice and of course the drug co and provider will not tell you to take less! But as long as I don't see an increase in symptoms, I plan to continue.