Hi bob, even when you take these meds. sometimes they have to be adjusted if you get symptoms or they don't work that well. I tried several. The one that helps me is Zoloft. I get no side effects, and it did reduce anxiety and depression up to a point. It doesn't take away my medical conditions, but it helps me to cope better. I have been on this for about 2 years. I wish you all the best. ginnie