Yes, Nexium blocks B12 because it reduces acid that is needed for intrinsic factor to aid absorption.

When you take B12 extra in this situation, you BYPASS intrinsic factor action, and absorb passively in the small intestine instead.
This is why empty stomach is important as presence of food will impair this second way--the passive absorption.

Nexium works systemically, and should be in your system when you take the supplements from the day before.

The acid blocking drugs impair the absorption of:
B12
folate
Calcium
Magnesium
Iron
zinc

These are the ones so far that have been evaluated.

R-lipoic stabilized is water soluble and a very small amount and should not upset the stomach. The old alpha lipoic racemic mixture had to be used in very high doses, and some people complained about that. Taking the old one also with food reduces its absorption about 30% however.

The stabilized form of R-lipoic is very easy to tolerate because the dose is so much smaller. I take it on an empty stomach just for insurance because the older version showed absorption interference with food.

You should take the B12 and Lipoic on an empty stomach.
All the rest may be taken with food. It does not matter if you take the nexium an hour later.