SAMe does not have any interactions that I know of.

The only warning it carries is for bipolar patients, who might get
hyped up on it and not realize. But even then it is a mild warning, not a big one.

Here is a long monograph:
http://www.umm.edu/altmed/articles/s...ine-000324.htm

I don't think it will have any negative effect on the gabapentin, and may in fact improve your cognition which is a common side effect of gabapentin.

It is really a great supplement and just a few months ago had the price decrease, at Costco's. I joined Costco in fact over a decade ago, just to buy it---since it was lower price there. All the money I saved payed for my membership several times over in fact back then.

There is a guarantee on NatureMade's website...if you don't like it you can return it (free shipping) for a full refund, with receipt and unused portion.

The drug interactions listed are the same as for serotonin increasing drugs. But since the SAMe is not increasing it so high like drugs do, the warning is basically a "cover your butt" warning. For people taking SSRIs or SNRIs, the warning is germain and should be followed however.

I didn't find SAMe much help for my PN, so I don't bring it up here often. But it is very good for joint and tendon issues.