I have been on Topomax for migraines for a couple of years. I don't have MS. It has worked very well for me. It is usually prescribed at a lower dose than for seizures. They usually start at a low dose and up it until it has an effect on the migraines. I now take 100 mg twice a day. I had some side effects at first but they lessened after I was on the med for a little while. This has made a big difference in controlling my migraines.