Originally Posted by glenntaj

--are the standard celiac/gluten panel--but they should also measure total IgA, as low total IgA--a common finding--can skew the results of the IgA gliadin and IgA tranglutaminase tests.

There are people who have negative serology who do show villious atrophy on biopsy (some correspondents who are represented in the Gluten File say this may happen into up to 20% of biopsy-proven celiacs). Generally, the anit-transglutaminase assay is more closely correlated with extent of intestinal damage, but there are exceptions.

A number of pharmaceutical companies have been working on "next generation" celiac testing that would be more specific, but none have reached the market yet.