Do you know if they tested her for JCV antibodies yet Amy? I am curious because the test is not limited to Tysabri patients, it's for use for anyone on any drug that has risk of PML. I am guessing that your mom has been on many drugs for both RA and scleroderma. I think the concern about previous immune suppressants has or should have been taken into account by her doctor who prescribed the Rituxan, but it wouldn't hurt to ask questions if you are involved in assisting her with her health care choices.

I was in my infusion center and overheard the nurse in the cube next door doing the standard talk to a patient who was starting Rituximab. It sounded a lot like the Tysabri warning, but seemed to have more side effects listed. I do know that the patient had some sort of reaction during his infusion, but have no details on what was going on other than there was a commotion. I do know they resumed the infusion at a slower rate and gave him IV Benadryl just like they would with Tysabri.

Please let us know how it goes for her. I hope it helps!