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Old 04-19-2012, 06:03 AM
glenntaj glenntaj is offline
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glenntaj glenntaj is offline
Magnate
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
Default There's a lot of controversy--

--regarding that question.

Dr. Hadijvassiliou's work seems to suggest that many people with neurological presentations of gluten problems, with or without concommitant gastrointestinal symptoms, may only show up with a isolated abnormal anti-gliadin IgG and/or anti-gliadin IgA; this may be due to the fact that the anti-transglutaminse IgA is the test for which abnormal figures are most associated with villous atrophy (you probably ran across this in the Gluten File) and such people do not typically have large-scale atrophy (or at least, not yet). There's also the suspicion that people who present that way may have a different genetic profile--HLA-DQ1, as opposed to the HLA-DQ2/DQ8 types more closely associated with celiac.

But then again, as many as 20% of people with biopsy-proven celiac show up negative on the anti-IgA tranglutaminase.

The tests results you've listed certainly don't constitute a definite bell-ringing diagnosis. But there's enough variability in the tests to say it's not an absolute negative, either. You could always try a gluten-free trial just to see if things get better symptomatically--no one needs to give anyone permission for that.
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