I was on copaxone for about 5 months and had the same problems with baseball size welts. I hated them. However I think I would have stayed on it if I had not experienced so many IPIR's. In fact, I did try it once again after being taken off of tysabri but a few hours after the very first injection, my temperature shot up to 103 and I was shaking with a fever for several hours. Since this was an uncommon side effect, my neuro told me to stop. I also experienced reactions during the ty infusions and developed antibodies. I was pulled off of it after going into severe shock.