Here is a study comparing oral with injectable.
Quote:
Arch Intern Med. 2005 May 23;165(10):1167-72.
Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial.
Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WH, van Staveren WA.
Source
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Abstract
BACKGROUND:
Supplementation with high doses of oral cobalamin is as effective as cobalamin administered by intramuscular injection to correct plasma markers of vitamin B(12) deficiency, but the effects of lower oral doses of cobalamin on such markers are uncertain.
METHODS:
We conducted a randomized, parallel-group, double-blind, dose-finding trial to determine the lowest oral dose of cyanocobalamin required to normalize biochemical markers of vitamin B(12) deficiency in older people with mild vitamin B(12) deficiency, defined as a serum vitamin B(12) level of 100 to 300 pmol/L (135-406 pg/mL) and a methylmalonic acid level of 0.26 mumol/L or greater. We assessed the effects of daily oral doses of 2.5, 100, 250, 500, and 1000 mug of cyanocobalamin administered for 16 weeks on biochemical markers of vitamin B(12) deficiency in 120 people. The main outcome measure was the dose of oral cyanocobalamin that produced 80% to 90% of the estimated maximal reduction in the plasma methylmalonic acid concentration.
RESULTS:
Supplementation with cyanocobalamin in daily oral doses of 2.5, 100, 250, 500, and 1000 mug was associated with mean reductions in plasma methylmalonic acid concentrations of 16%, 16%, 23%, 33%, and 33%, respectively. Daily doses of 647 to 1032 mug of cyanocobalamin were associated with 80% to 90% of the estimated maximum reduction in the plasma methylmalonic acid concentration.
CONCLUSION:
The lowest dose of oral cyanocobalamin required to normalize mild vitamin B(12) deficiency is more than 200 times greater than the recommended dietary allowance, which is approximately 3 mug daily.
PMID:
15911731
[PubMed - indexed for MEDLINE]
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Because in the past it was believed that oral was not an effect route, injectable was the only treatment given for B12 deficiency. Now there are studies showing oral works as well.
Studies cost money to produce, and B12 is not a drug where lots of money or patents are at stake. So finding reliable data on sublingual is not common.
The size of the drug molecule and its lipid solubility, determine success with sublingual administration. Both of these traits are missing for B12, which is very water soluble, and a huge molecule.
Because of the lack of data that is reliable on sublingual forms, most comments on scientific sites are like this one:
Quote:
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In addition to oral dietary supplements, vitamin B12 is available in sublingual preparations as tablets or lozenges. These preparations are frequently marketed as having superior bioavailability, although evidence suggests no difference in efficacy between oral and sublingual forms.
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from
http://ods.od.nih.gov/factsheets/vit...hProfessional/
Certainly you can do whatever you like. I just suggest if you choose sublingual, keep it there for a LONG TIME and don't swallow. Most people find this difficult. Some complain of mucus membrane irritations, as well. To get the most potential from a sublingual given its lack of data ...do this on an empty stomach.
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Weezie looking at petunias 8.25.2017
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