Ive been taking ibuprophen and benadryl. I worry about the long term side effects of using these. However, I do limit myself. The ibuprophen I will only take once a day and onlyvif I'm having a bad day. I take 50 Mg of benadryl everynight. I started doing this because a nurse practicioner told me that would help with anxiety but it also seems to help with my PN for some reason.