People who don't understand and who don't care to understand (or even try to)...their opinions don't matter one fig to me or those who care about me. I only care about advice and opinions from those who have taken the time to try to KNOW what they are talking about (either from trying to educate themselves or from their own experience). Sorry your wife has to deal with it too. I've been pretty lucky that all the people I care about are understanding and supportive...it's only the people at work who really don't seem to get it because they don't care to. Which is fine...I don't need their advice and opinions about my health and what I am going through...so I generally just ignore the ignorant or stupid comments and go about my life as I know I need to.