Mrs. D, just a little segue from the main topic, is it safe to increase my dosage of SAM-e from 200mg to 400mg and then later back to 200mg? I know SAM-e 200mg is working for my arthritis but my fingers are stiff in the morning and always painful. My right pinky is still swollen but not as swollen as it used to before taking the SAM-e. I am wondering if it is better/safe to just take it slow with the 200mg, or increase the dosage to 400mg then back to 200mg when my pain has subsides. I have finished 28 tablets now.

Thank you.