If you don't have troubling side effects from the SAMe ...then you can raise it to 400mg a day... take it all at once in the morning on an empty stomach.
If it is not agitating you or giving insomnia, then you can increase.
I didn't get the joint effects until I was taking 600mg a day
for a while. I think the mood effects come first, and the repair of damage takes a while.
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Weezie looking at petunias 8.25.2017
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