There is a significant interaction between Elavil and Neudexta:
http://www.drugs.com/interactions-ch...-74,3281-14874
This is metabolic and occurs at the liver enzyme level.
If Elavil builds up in system, it can affect the heart.
Seems to me if you needed "more" effects from Neudexta, you could just take a bit more DM... and not increase that quinidine to dangerous levels. It is the DM affording the pain relief.
You can buy DM OTC in liquid form called Delsym.
This drug is highly problematic. And in combination with Elavil VERY problematic. Should you become low in potassium and magnesium (say from a stomach virus), you could have a QT event. IMO you are in a dangerous spot, with that dosage increase.
Here is more information on QT events:
http://www.azcert.org/
It might be to your advantage to have the DNA testing for liver metabolism of drugs...
This is now affordable and would reveal errors in metabolism before you have some serious event:
https://www.23andme.com/?gclid=CJKBk...FQVoKgodHlOsDg
detail:
http://spittoon.23andme.com/2011/10/...zing-medicine/
One of our PN members did this test and discovered she did not have good metabolic enzymes for 3 families of drugs! Pretty soon everyone will be tested so that serious drug events can be avoided.
Quote:
Originally Posted by perplexed
I have been taking Neudexta for about a year now. I started with the prescribed dosage on once in the morning, and once in the evening. The med was making a noticeable difference in my daily life, but after a few months my neuropathy was beginning to creep back into my life. I met with my very accredited neurologist, and we have increased my dosage to two pills twice a day. To an extent my symptoms are restrained, however I still have a problem with , not so much pain but, discomfort that never subsides.
I have been through nearly every test and exam and remain undiagnosed. I have seen the warning against taking Nuedexta with Elavil, however I have been a long time user of Elavil and have not noticed any adverse side effect. In fact, most of the side effects of the combination are the symptoms that the Nuedexta is suppressing; go figure.
so currently, I am taking
Neudexta 2capsuls PO 2x daily
Elavil 100mg 1x nightly
I guess im just open to anyone's thoughts or ideas on where I could possibly go from here. By "here" i mean being undiagnosed and exhausted.
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Weezie looking at petunias 8.25.2017
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