Hi Dave, welcome to Neurotalk!! Sorry to hear about the skin cancer problem. I get Tysabri every 8 weeks and it still works for me...after the 17th infusion I switched to the 8 week cycle because of too many infections. And I'm going on 4 years on it total. I have heard there are more problems with Gilenya and skin cancer. I do know there are a couple of new drugs that will be out in a year or so. One is a pill by Biogen and my doc said the latest great results blew everyone out of the water. I hope you can find something that your body can handle. Good luck!