I guess it would depend on what your triggers are. I am very bothered by noise, so it helped me to have headphones in and listen to music once we were allowed to use our electrical devices. I also am very bothered by cold so I made sure I had one of my heating pads on my ankle (at the time of my last plane ride that was the only area I had RSD). I also ran myself through my physical therapy exercises that I could do while in my seat to keep my ankle moving. For me...anything that I could use to distract me what a good thing. And try not to stress out too much because that in and of itself can cause a flare. Good luck!