If anybody with a history of TBI/mTBI will be traveling to an area with risk of malaria, mefloquine hydrochloride ((also known as Lariam or Mefaquin) is strongly contra-indicated. it's an orally administered medication used in the prevention and treatment of malaria. It can cause paranoia, hallucinations and other psychotic episodes. The US DoD states: Mefloquine is specifically prohibited in the treatment of patients with head injuries, and in particular, a TBI (traumatic brain injury). It is also contraindicated for patients with post-traumatic stress disorder.

There is some question that Sgt Bales, the soldier who went on a killing rampage in Afghanistan may have been treated with it prior to his episode. He had a documented history of TBI.