Do your research. I know you have looked up the odds, but have you looked up what happens to that 1 in 400? have you seen the heart crushing videos of those that woke one morning feeling great, and then the next unable to feed themselves? Have you contacted anyone who has gotten PML? They usually welcome contact. Have you spoken to those that have been on it long term and have had not a single thing go wrong, other than it helped?

As long as you are making an informed choice, and not one with your fingers crossed and your eyes closed I will cheer lead you all day. Please dont make such a sizeable choice based on a wish. There are too many unknowns in this silly disease. Arm yourself and then decide.

if it were me on #40 and was found to be + I would stop. Ima chikin and scared to death of that stuff, but thats just me. i wish you the best of luck, no matter what you chose.