You can try injecting deeper. if your auto inflictor is set too shallow it will leave a lump. That angry bees on steroids feeling does get better with some time. It can also take up to one full year for C to start showing that its working. its a long haul med, not a short sprint. it takes commitment to pick that one.

Try ice before. if that doesnt work, try heat. DONT RUB! There are sharp crystals in that drug, and when you rub or press hard, it shatters the crystals and causes those dents.

Pick a time when you know you can sit back, and relax for at least one hour after the shot. its a med worth trying, but if you continue to have IPIRs then it means you are either shooting into a vascular space or its a huge panic attack from the injection itself.

I used the outter edge of my thighs instead of shooting straight on. Each time I poked the top side of my thigh I got huge lumps and ended up with IPIR. I couldnt shoot deeply enough. So, I switch to the side wall which has much more fat to choose. I sometimes would shoot the back wall.

Call the Copaxone folks and ask them for tips, tricks or retraining if you are really committed to doing this. Its a tricky drug and it doesnt take much to throw you into the lumpy/stingy/IPIR/im gonna quit this lane. In the end if you decide you simply cant/wont do this anymore then at least you know you tried hard.

good luck. ((Hugs))