So I have had more than a couple advanced pharmacology classes but this is complicated because the brain is so complex and the neurotransmitters act in different ways in different parts of the brain. This won’t explain much but here are some interesting tidbits.

Naltrexone is an opioid antagonist which means it blocks the effects of opioids in the brain. Opioids regulate dopamine pathways in areas of the brain linked with impulse control disorders. It is often given to alcoholics as a medication that will hopefully reduce cravings by blocking the dopamine pleasure seeking aspect. It is also being studied with impulse control disorders in Parkinson’s Disease, Crohn’s and as an adjunct for chronic pain control.

http://clinicaltrials.gov/ct2/show/NCT01052831

http://downeastpharmaservices.com/wp...tsForPain1.pdf

I read an article that indicated the reason it is thought to be helpful in MS is related to a decrease in pre-programmed cell death of oligodendrocytes. The principle function of oligodendrocytes is to provide support to axons and to produce the Myelin sheath, which insulates axons. http://www.fromvoulevs.com/download/agrawal_2005_ms.pdf

Which is interesting however there have been quite a few LDN studies on MS that haven't been conclusive.
http://www.ptsr.org.pl/pl/files/2010...rology_110.pdf
doi: 10.1177/1352458508095828 Mult Scler September 2008 vol. 14 no. 8 1076-1083





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