I don't remember the name of the first generic Sinemet I took but it worked pretty well. Then my pharmacy/insurance company switched to one made by Actavis and it's basically crap. I noticed a huge difference right away. Like you, I thought maybe I got a bad batch but the next refill had the same results. I really notice the difference when I take a Parcopa (orally dissolving Sinemet). The difference is HUGE!

I take Remeron and Xanax for depression/anxiety/sleep and can only take the brand name because the generics make me sick as a dog.

I'm amazed at just how different the generics are from the brands and how our body's certainly know the difference!

Todd
PDTalks.com