I started Imuran 50mg at dinner time three weeks ago. I'm already on Mestinon (about 150 mg/day) and 15 mg Prednisone/day. For the last few days, I have been feeling like I overdose on my first dose of Mestinon of the day. I take 60 mg in the morning with food. I'm wondering about your opinions of whether this overdose feeling could be that the Imuran is kicking in and that I don't need as much Mestinon? I intend to lower the Mestinon to 30 in the morning, but wanted to hear from those with Imuran experience if this sounds familiar.