I took Savella...it didn't do much for me but it was supposed to help with the burning pain. I was suffering from seratonin syndrome (undiagnosed at the time) when I was started on it though and then had a horrible reaction when Cymbalta was added to the mix. The bad reaction may or may not have been related to an interaction with the savella or tramadol but doctor thinks most likely it's because I was already suffering from seratonin syndrome and adding the Cymbalta put me over the edge. It was a very scary time with me to be dealing with all that at the same time as my RSD was spreading unchecked.