I have been on Imuran for a year. I have not noticed any side-effects, though some people have digestive problems with it, and sometimes it's an appetite-suppressant. I hear that it's generally well tolerated, though you'll need regular blood tests while on it. It made Mike (PingPongMan, on this forum) really sick.

It takes a long time to work. I'm still waiting. Prednisone is faster, but the side effects are pretty severe, from what I hear.

If you go on Imuran, you should make sure your doctor gives you a blood test first to make sure you don't have a genetic condition that makes you unable to metabolize it. The test is called a TPMT screening.

Abby