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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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JohnT-
Some environmental factors to work in neuroinflammation as a common feature-
1) Nanoparticles from diesel exhaust seems to have made areas of Mexico City a place of keen interest for PD research. See
Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease.
Levesque S, Surace MJ, McDonald J, Block ML.
J Neuroinflammation. 2011 Aug 24;8:105.
PMID:
21864400
[PubMed - indexed for MEDLINE]
Free PMC Article
Related citations
2.
Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain.
Gerlofs-Nijland ME, van Berlo D, Cassee FR, Schins RP, Wang K, Campbell A.
Part Fibre Toxicol. 2010 May 17;7:12.
PMID:
20478040
[PubMed - indexed for MEDLINE]
Free PMC Article
Related citations
3.
Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase.
Block ML, Wu X, Pei Z, Li G, Wang T, Qin L, Wilson B, Yang J, Hong JS, Veronesi B.
FASEB J. 2004 Oct;18(13):1618-20. Epub 2004 Aug 19.
PMID:
15319363
[PubMed - indexed for MEDLINE]
Free Article
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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