My dr. put me on it a few weeks ago but recently wined me of our cause we noticed a large increase in swelling in my left foot/ankle which is the area of my rsd. she said it was a rare side effect.go figure I would be one of the few but since then the swelling has decreased so I would say its worth a try. I've tried several things and I'm sure I'll keep trying things til I find something that works. Its th nature of our rsd I guess. No two people are the same. Good luck to you. I hope you find relief.