ahhhh fatigue... interesting question. see i suffer insomnia except when i take Lyrica. when i take that its different. as I will pass out early morning. until I awake at 6am.. as far as fatigue hmmm sleepy not really, worn down or better yet run down and emotionally and mentally exhausted , physically Im not so sure.. its not like I can do much. maybe..IDK.. I'm not really sure which kind of fatigue you r asking about...