In each appendage as it spreads. at first nail growth was fast and thin nails with groves showing up against the natural grain of the nail. now .I still have the groove thing but the nails ar really thick , barley grow and when i do need to clip the crumble immediately . also splitting of the nails happen often so i am forever filing the rough edges out to stop snags... and I suffered massive hair loss in lower appendages, and my hands. these parts used to be very hairy now i see little to no hair.. and swelling is very bad. my wedding ring no longer comes off my finger is starting to look like the trunk of a tree that grew around a rope or wire...