I am posting in behalf of my husband who has been on Nexium for many years now. After having been on this forum for a while now, I put him on Vit.B12. After reading some of the serious side effects of long term use of Nexium, we shifted to Ranitidine, hoping that it would have fewer side effects than Nexium. At first, he was taking 2 tabs 2x a day, but was not working as good as Nexium. So, what we did, we split the 2 tablets into 4 and take it 4x spaced evenly during the day. Surprisingly, it seems to be working!