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Old 06-24-2012, 04:08 AM
Diego24
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Diego24
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Quote:
Originally Posted by d0gma View Post
http://www.pnas.org/content/early/20...56108.abstract

Is this the article? Interesting indeed.
Dogma, this is not the article I mentioned. The article I mentioned is located somewhere on this site http://www.parkinsons.org.uk. It is some 2012 summer or spring or winter report. I would post the link but I just don't know where to find it anymore.

The article interviewed some researcher and asker her about what she thinks was the most promising yet found. She said that the alpha-synuclein path was one of the most remarkable things. But then she also started talking about something she was doing research on which was about a way to get proteins past the blood-brain barrier.

If I understood well the technique works by capturing the PD "curing" protein inside some closed sphere. The sphere hides the protein and is capable of entering the blood brain barrier. Once inside the brain, the protein is released and can start "curing" PD. This is really an important breakthough. Why ? For example, growth factors can't enter the blood brain barrier. With this technique it could enter very easily. So you wouldn't need these scary gene therapy technique in which they insert a needle in your brains and insert a virus. Also, researcher find many proteins and molecules that show they slow down or cure PD in animals but that are useless for people because the products don't cross the blood brain barrier. This is what happens with curcumin. So what researcher do next is try to modify these products so they do enter the brain barrier. But this is time consuming and slows down the cure. With this new technique you can get anything in the brain which speeds up the quest to find the cure. So I am very delighted about this research.

UPDATA: I found the article ... p. 14-15 of http://www.parkinsons.org.uk/pdf/Pro...winter2012.pdf This researcher will test exosomes to deliver meds to the brain. So it is still in the research phase and not yet proven to work well.
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