We actually were taking isradipine for quite awhile (from a willing doc who scripted it for us) but were not able to discern any benefit whatsoever, nor did our neuro. It's a calcium channel blocker, if I remember correctly, and while it may do that, I think there is so much else going on that simply trying to keep excess calcium from building up in the cell just isn't enough to really make a difference. This is our personal experience, though, and subjective observations, trial of one, and mere lay opinion.