Thanks MrsD.

I really thought Plaquenil was used quite a bit with up to 50 million people with autoimmune disease and it's first line for Sjogrens. RA, and even pretty widely used in Lupus as well. I know at least 3/4 of the Sjogren's board uses it..with the other 1/4 trying alternative / natural supplements and of course a few that had side-effects and had to stop.

Pruritus is about .57%, so not many, but I now think she it's possible she had a reaction to the Plaquenil that may have permanently damaged the nerves (since it didn't go away after stopping it...actually it got worse and started the pain after resolving the itch.

I wouldn't take it again, if I were her....AND BY ALL MEANS, IdiopathicPN should stay Flouroquinilones also based upon what Mrs D found...for multiple reasons now.

Sadly, I think every treatment has side effects of some sort. It's almost like having to choose the disease effects or the consequences for the treatment. This is when most us of turn toward something natural like vitamin supplements and balanced diets. Sometimes it works, sometimes it doesn't....both it's worth the try.

There was more info on the site MrsD provided that I wanted to comment on, but it crashed while I was using it and now it won't come up (an hour later). I'll check again in the morning and edit my posted if possible.