From my understanding from my neuro, rebif and avonex are like "sister" drugs with betaseron. Meaning, you'd probably get the same reactions from all those meds. Like flu like symptoms, etc. Im on copaxone, have been since February. Ive had several IPIRs, have alot of lumps at the injection sites, itching at the sites, losing my hair, etc, but I chose to stay on it because it is the lesser of the evils, so to speek. My neuro wants me on Tysabri so bad, but Im terrified of the brain infection ... He wants me to take the jc virus test, thing is, just because I test negative now, doesnt mean I will be negative if I ever do decide to try it. You can be exposed at any time. I have a friend on Gilenya, she has severe migraines that last for weeks. Her spasms are worse than before she started. From everything I have read, the new med coming out I believe this year, I could be wrong, but they have said it has the same side effects as Gilenya. If copaxone doesnt work for me, I will be done with dmd's. I'd rather suffer thru flares than be done in by a dmd thats suppose to help me.